23WO image
Deposition Date 2026-02-23
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
23WO
Keywords:
DE NOVO PROTEIN
Title:
Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
23WO validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DP221
Chain IDs:A
Chain Length:1503
Number of Molecules:1
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Amyloid-beta protein 42
Gene (Uniprot):APP
Chain IDs:B
Chain Length:42
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P05067 Pfam ID:PF03494
Ligand Molecules
ZN
Primary Citation
De novo design of metalloproteases for targeted amyloid-beta cleavage
Vita ? ? ? (2026)
DOI: 10.15302/vita.2026.07.0055
Primary Citation of related structures
23WO
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