ISDA: 23VF

Deposition Date 2026-02-20

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

23VF

Keywords:

CELL ADHESION

Title:

Crystal structure of CEACAM1 in complex with MG1124 antibody

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:MG1124 Light Chain
Chain IDs:A, C
Chain Length:215
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MG1124 Heavy Chain
Chain IDs:B, D
Chain Length:231
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Cell adhesion molecule CEACAM
Chain IDs:E, F
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

SO4

Primary Citation

Preclinical characterization and efficacy of MG1124, a CEACAM1-targeting immune checkpoint antibody for cancer immunotherapy

Oh, B.-H, Kim, S, Lee, C.-W, Lee, J.-C, Oh, M.-Y, Nam, H.-M, Cho, H.-J, Kim, J, Cho, B.C.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form