ISDA: 23PS

Deposition Date 2026-02-12

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

23PS

Keywords:

VIRAL PROTEIN

Title:

CryoEM structure of EV-D68 US/KY/14-18953 in complex with MFSD6-L3

Biological Source:

Source Organism(s):

enterovirus D68 (Taxon ID: 42789)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.65 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Capsid protein VP1
Chain IDs:D (auth: A)
Chain Length:295
Number of Molecules:1
Biological Source:enterovirus D68

UniProt ID:A0A8D5ZMD3 EC:3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Capsid protein VP2
Chain IDs:A (auth: B)
Chain Length:238
Number of Molecules:1
Biological Source:enterovirus D68

UniProt ID:A0A097BW19 EC:3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Capsid protein VP3
Chain IDs:B (auth: C)
Chain Length:247
Number of Molecules:1
Biological Source:enterovirus D68

UniProt ID:A0A097BW19 EC:3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Capsid protein VP4
Chain IDs:C (auth: D)
Chain Length:39
Number of Molecules:1
Biological Source:enterovirus D68

UniProt ID:Q68T42

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Major facilitator superfamily
Gene (Uniprot):MFSD6
Chain IDs:E
Chain Length:133
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6ZSS7

Ligand Molecules

Primary Citation

A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry.

Liang, S, Guo, H, Xu, Z, Liu, Z, Yang, W, Liu, X, Wei, Z, Hou, J, Huang, W, Wang, W, Li, J, Ma, W, Deng, Z, Qian, H, Wang, Y, Liu, J, Rao, Z, Wei, W, Lou, Z.Show

Nat Commun 17 ? ? (2026)

PMID: 42637770 DOI: 10.1038/s41467-026-75856-2

Primary Citation of related structures

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