ISDA: 23MG

Deposition Date 2026-02-11

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

23MG

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-CoV-2 main protease S144A mutant in complex with leritrelvir

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.23

R-Value Work:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Mutagens:S144A
Chain IDs:A, B
Chain Length:312
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules

A1EN0

GOL

Primary Citation

Superior Target Binding by Leritrelvir Induces Dimerization of Mpro Mutants and Mitigates Drug Resistance

Huang, X, Kuzmic, P, Zhang, S, Chen, X, Gui, J, Li, Q, Zou, B, Yan, S, Song, L, Niu, C, Zhao, Y, Lin, H, Wang, N, Chen, J, Chen, X, Chen, J, Zhong, N, Yang, Z, Xiong, X.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form