ISDA: 23MC

Deposition Date 2026-02-11

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

23MC

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-CoV-2 main protease M49I mutant in complex with leritrelvir

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.87 Å

R-Value Free:

0.21

R-Value Work:

0.17

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Mutagens:M49I
Chain IDs:A, B
Chain Length:312
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules

7ON

GOL

Primary Citation

Superior Target Binding by Leritrelvir Induces Dimerization of Mpro Mutants and Mitigates Drug Resistance

Huang, X, Kuzmic, P, Zhang, S, Chen, X, Gui, J, Li, Q, Zou, B, Yan, S, Song, L, Niu, C, Zhao, Y, Lin, H, Wang, N, Chen, J, Chen, X, Chen, J, Zhong, N, Yang, Z, Xiong, X.Show

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