ISDA: 23LZ

Deposition Date 2026-02-11

Release Date 2026-06-03

Last Version Date 2026-06-24

Entry Detail

PDB ID:

23LZ

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-CoV-2 main protease G143S mutant in complex with leritrelvir

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.97 Å

R-Value Free:

0.24

R-Value Work:

0.20

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Mutagens:G143S
Chain IDs:A, B, C, D
Chain Length:306
Number of Molecules:4
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules