23LZ image
Deposition Date 2026-02-11
Release Date 2026-06-03
Last Version Date 2026-06-03
Entry Detail
PDB ID:
23LZ
Keywords:
VIRAL PROTEIN
Title:
Crystal structure of SARS-CoV-2 main protease G143S mutant in complex with leritrelvir
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.97 Å
R-Value Free:
0.24
R-Value Work:
0.20
Space Group:
P 21 21 2
23LZ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Mutagens:G143S
Chain IDs:A, B, C, D
Chain Length:306
Number of Molecules:4
Biological Source:Severe acute respiratory syndrome coronavirus 2
UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48
Ligand Molecules
7ON
GOL
Primary Citation
Superior Target Binding by Leritrelvir Induces Dimerization of Mpro Mutants and Mitigates Drug Resistance
To Be Published ? ? ? (?)
Primary Citation of related structures
8IGN
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