ISDA: 23JW

Deposition Date 2026-02-09

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

23JW

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of human cytosolic NADP(+)-dependent malic enzyme in a ternary complex with NADP+ and Mn2+

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.31 Å

R-Value Free:

0.23

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADP-dependent malic enzyme
Gene (Uniprot):ME1
Chain IDs:A, B (auth: C), C (auth: B), D
Chain Length:0
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P48163 Pfam ID:PF00390, PF03949 EC:1.1.1.40

Ligand Molecules

NAP

Primary Citation

Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.

Cao, S.Y, Hu, K, Huang, S, Guan, X.L, Wang, J, Shen, Y, Ming, H, Gu, A, Wang, C, Shen, X, Wu, Q, Chen, Z, Yin, M, Wen, W, Lei, Q.Y.Show

Signal Transduct Target Ther 11 ? ? (2026)

PMID: 42728262 DOI: 10.1038/s41392-026-02839-6

Primary Citation of related structures

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