ISDA: 23FW

Deposition Date 2026-02-05

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

23FW

Keywords:

TRANSFERASE

Title:

Crystal structure of human PKMYT1 protein kinase domain with Naphthyridinone Inhibitor compound 16

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.59 Å

R-Value Free:

0.19

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Membrane-associated tyrosine-
Gene (Uniprot):PKMYT1
Chain IDs:A, B
Chain Length:286
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99640 Pfam ID:PF00069

Ligand Molecules

A1E5J

DMS

EDO

SO4

Primary Citation

Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors

Xu, Z.H, Chen, S.Show

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Primary Citation of related structures

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