23FD image
Deposition Date 2026-02-04
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
23FD
Keywords:
NUCLEAR PROTEIN
Title:
Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS, Chk1 and TopBp1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
23FD validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Chain IDs:A, B
Chain Length:2644
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:ATR-interacting protein
Chain IDs:C, D
Chain Length:791
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Chain IDs:E, F
Chain Length:14
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:DNA topoisomerase 2-binding p
Chain IDs:G, H
Chain Length:545
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
AGS
MG
ZN
Primary Citation
Mechanistic insights into phosphorylation-driven activation and therapeutic inhibition of human ATR-ATRIP
To Be Published ? ? ? (?)
Primary Citation of related structures
23FD
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