ISDA: 23EX

Deposition Date 2026-02-04

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

23EX

Keywords:

NUCLEAR PROTEIN

Title:

Cryo-EM structure of human ATR-ATRIP complex with Ceralasertib

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Chain IDs:A, B
Chain Length:2644
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:ATR-interacting protein
Chain IDs:C, D
Chain Length:791
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1E5B

Primary Citation

Mechanistic insights into phosphorylation-driven activation and therapeutic inhibition of human ATR-ATRIP

Wang, L, Wang, M, Zhao, L, Rao, Q, Wu, H, Ma, B, Wang, J, Zheng, J, Li, Y, Xu, Y, Guo, J, Cheng, J, Qiao, S.Show

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