23CV image
Deposition Date 2026-02-01
Release Date 2026-10-14
Last Version Date 2026-10-14
Entry Detail
PDB ID:
23CV
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of the MRGPRX4-miniGsq complex bound to the agonist dexamethasone phosphate (DEX-P)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.97 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
23CV validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Gs-mini-Gq chimera
Chain IDs:A (auth: B)
Chain Length:246
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B (auth: C)
Chain Length:358
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: D)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768
Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:D (auth: E)
Chain Length:267
Number of Molecules:1
Biological Source:Mus musculus
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Mas-r
Gene (Uniprot):cybC, MRGPRX4
Chain IDs:E (auth: R)
Chain Length:472
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens
UniProt ID:P0ABE7,Q96LA9
Ligand Molecules
3T5
Primary Citation
Cryo-EM structure of the MRGPRX4-miniGsq complex bound to the agonist dexamethasone phosphate (DEX-P)
To Be Published ? ? ? (?)
Primary Citation of related structures
23CV
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