23BB image
Deposition Date 2026-01-30
Release Date 2026-06-24
Last Version Date 2026-06-24
Entry Detail
PDB ID:
23BB
Keywords:
IMMUNE SYSTEM
Title:
Caspase-4 p20/p10 and human GSDMD
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
23BB validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Gasdermin-D
Gene (Uniprot):GSDMD
Chain IDs:E (auth: A)
Chain Length:484
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P57764 Pfam ID:PF04598, PF17708
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Caspase-4
Gene (Uniprot):CASP4
Mutagens:C258A
Chain IDs:A (auth: B), B (auth: E)
Chain Length:166
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49662 Pfam ID:PF00656 EC:3.4.22.57
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Caspase-4
Gene (Uniprot):CASP4
Chain IDs:C, D
Chain Length:88
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P49662 Pfam ID:PF00656 EC:3.4.22.57
Ligand Molecules
NA
Primary Citation
Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D
Structure ? ? ? (2026)
Primary Citation of related structures
23BB
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