22XC image
Deposition Date 2026-01-26
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
22XC
Keywords:
SIGNALING PROTEIN
Title:
Structure of CXCR4 in complex with a de-novo designed mini-protein antagonist
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli, Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.28 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
22XC validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:dCX001 binder antagonist
Chain IDs:A, B, D
Chain Length:87
Number of Molecules:3
Biological Source:synthetic construct
UniProt ID:22XC
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:C-X-C chemokine receptor type
Gene (Uniprot):CXCR4
Chain IDs:C, E (auth: G), F (auth: R)
Chain Length:408
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P61073 Pfam ID:PF12109, PF00001
Ligand Molecules
CLR
D21
Primary Citation
Structure of CXCR4 in complex with a de-novo designed mini-protein antagonist
To be published ? ? ? (?)
Primary Citation of related structures
22XC
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