ISDA: 22WR

Deposition Date 2026-01-26

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

22WR

Keywords:

MEMBRANE PROTEIN

Title:

local refinement of 5HT2AR-miniGq heterotrimer in complex with a selective agonist IHCH-2330

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:5-hydroxytryptamine receptor
Chain IDs:A
Chain Length:336
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1EXY

Primary Citation

Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation

Tang, L, Ji, X, Wang, Y, Cao, D, Li, H, He, L, Cheng, J, Wang, S.Show

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Primary Citation of related structures

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