ISDA: 22VT

Deposition Date 2026-01-26

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

22VT

Keywords:

REPLICATION

Title:

Structure of human MCM2-7 single hexamer with MCM3-WHD attached to MCM2-CTD, containing Meier-Gorlin Syndrome mutation (MCM3-Q761L)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM2
Chain IDs:A (auth: 2)
Chain Length:904
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P49736 Pfam ID:PF12619, PF14551, PF17207, PF00493, PF17855, PF23669

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM3
Mutagens:Q761L
Chain IDs:B (auth: 3)
Chain Length:808
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P25205 Pfam ID:PF14551, PF17207, PF00493, PF17855, PF23191 EC:3.6.4.12

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM4
Chain IDs:C (auth: 4)
Chain Length:863
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P33991 Pfam ID:PF14551, PF17207, PF00493, PF17855, PF21128 EC:3.6.4.12

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM5
Chain IDs:F (auth: 5)
Chain Length:734
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P33992 Pfam ID:PF14551, PF17207, PF00493, PF17855, PF21933 EC:3.6.4.12

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM6
Chain IDs:D (auth: 6)
Chain Length:821
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14566 Pfam ID:PF14551, PF17207, PF00493, PF17855, PF18263 EC:3.6.4.12

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA replication licensing fac
Gene (Uniprot):MCM7
Chain IDs:E (auth: 7)
Chain Length:719
Number of Molecules:1
Biological Source:Homo sapiens