ISDA: 22TA

Deposition Date 2026-01-22

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

22TA

Keywords:

MEMBRANE PROTEIN

Title:

5HT2AR-miniGq heterotrimer in complex with a novel agonist IHCH-8152

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:5-hydroxytryptamine receptor
Gene (Uniprot):HTR2A
Chain IDs:A
Chain Length:336
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P28223

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2, GNAS
Chain IDs:B
Chain Length:326
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768,Q5JWF2 EC:3.6.5.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C
Chain Length:340
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873

Polymer Type:polypeptide(L)
Molecule:single-chain variable fragmen
Chain IDs:D
Chain Length:258
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1EEO

Primary Citation

Mechanisms Underlying Sustained Antidepressant Effects of Psychedelics Inspire Microdosing Strategies

He, L, Tang, L, Cao, D, Duan, W, Yu, J, Zhang, P, Li, H, Wang, Y, Meng, B, Wang, H, Zhou, Y, Li, W, Li, X, Liu, Z, Zhang, L, Li, L, Cheng, J, Wang, S.Show

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Primary Citation of related structures

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