ISDA: 22RD

Deposition Date 2026-01-21

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

22RD

Keywords:

TRANSFERASE

Title:

High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.38 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):PLK1
Mutagens:T210V
Chain IDs:A
Chain Length:333
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P53350 EC:2.7.11.21

Ligand Molecules

937

Primary Citation

High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit.

Park, K, Yoo, Y, Jeon, H, Choi, K, Kim, H, Kwon, E, Lim, H.H, Kim, D.Y, No, K.T.Show

Nat Commun ? ? ? (2026)

PMID: 41980966 DOI: 10.1038/s41467-026-71934-7

Primary Citation of related structures

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