22QU image
Deposition Date 2026-01-21
Release Date 2026-08-12
Last Version Date 2026-10-07
Entry Detail
PDB ID:
22QU
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of the Deg-3/Des-2 betaine-bound open state
Biological Source:
Source Organism(s):
Caenorhabditis elegans (Taxon ID: 6239)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
22QU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Acetylcholine receptor subuni
Gene (Uniprot):des-2
Chain IDs:A, C (auth: B), E (auth: C)
Chain Length:548
Number of Molecules:3
Biological Source:Caenorhabditis elegans
UniProt ID:O76554 Pfam ID:PF02931, PF02932
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Acetylcholine receptor subuni
Gene (Uniprot):deg-3
Chain IDs:B (auth: D), D (auth: E)
Chain Length:564
Number of Molecules:2
Biological Source:Caenorhabditis elegans
UniProt ID:P54244 Pfam ID:PF02931, PF02932
Ligand Molecules
BET
NAG
Primary Citation
Structural basis of ligand recognition and gating in a heteromeric Deg-3/Des-2 nicotinic acetylcholine receptor.
Proc.Natl.Acad.Sci.USA 123 e2608998123 e2608998123 (2026)
PMID: 42623446 DOI: 10.1073/pnas.2608998123
Primary Citation of related structures
22QU
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