ISDA: 22KK

Deposition Date 2026-01-14

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

22KK

Keywords:

IMMUNE SYSTEM

Title:

Cryo-EM structure of the BTNL3-BTNL8-TCR complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Butyrophilin-like protein 3
Chain IDs:A (auth: B), C (auth: A)
Chain Length:466
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Butyrophilin-like protein 8
Chain IDs:B (auth: C), D
Chain Length:500
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:TCR
Chain IDs:E (auth: G), G (auth: I)
Chain Length:293
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:TCR
Chain IDs:F (auth: H), H (auth: J)
Chain Length:322
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Butyrophilin-like 3 and 8 tetramers clamp V gamma 4V delta 1 T cell receptors for antigen-independent activation.

Dong, D, Li, H, Zhu, Y, Lu, Z, Zhu, J, Tian, X, Huang, Z.Show

Immunity ? ? ? (2026)

PMID: 42546693 DOI: 10.1016/j.immuni.2026.07.004

Primary Citation of related structures

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