ISDA: 22IZ

Deposition Date 2026-01-14

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

22IZ

Keywords:

PROTEIN BINDING

Title:

Crystal structure of MDM2 in complex with St3-R staple peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.52 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase M
Chain IDs:A, C
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:St3-R
Chain IDs:B (auth: D), D (auth: B)
Chain Length:16
Number of Molecules:2
Biological Source:Homo sapiens

Primary Citation

Crystal structure of MDM2 in complex with St3-R staple peptide

Konuma, T, Fujita, M, Demizu, Y.Show

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