ISDA: 22EM

Deposition Date 2026-01-08

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

22EM

Keywords:

SIGNALING PROTEIN

Title:

Gi bound kappa-opioid receptor in complex with beta01

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Bos taurus (Taxon ID: 9913)
Escherichia coli (Taxon ID: 562)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.86 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:A1E3Y-PHE-LEU-DLY-A1L9X
Chain IDs:E (auth: A)
Chain Length:5
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:22EM

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A (auth: B)
Chain Length:353
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B (auth: C)
Chain Length:371
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:P62874 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: D)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Kappa
Gene (Uniprot):cybC, OPRK1
Chain IDs:D (auth: F)
Chain Length:624
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens

UniProt ID:P0ABE7,P41145 Pfam ID:PF00001

Ligand Molecules

Primary Citation

Gi bound kappa-opioid receptor in complex with beta01

Zhang, H, Wang, R, Shi, P, He, X, Zhu, Q, Xu, Y, Yuan, Q, Hu, W, Wu, K, Zheng, Y, Zhou, L, Liang, J, Lv, P, Xu, Z, Zhuang, Y, Xu, H, Wang, Y, Tian, C.Show

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