21TW image
Deposition Date 2025-12-24
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
21TW
Keywords:
CYTOKINE
Title:
Cryo-EM structure of TNF-alpha in complex with two anti-TNF-alpha nanobodies, TNF30, derived from the TNF-alpha inhibitor Ozoralizumab (OZR)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Cricetulus griseus, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.43 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
21TW validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:anti-TNF-alpha nanobodies, TN
Chain IDs:A
Chain Length:363
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:21TW
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor
Gene (Uniprot):TNF
Chain IDs:B, C, D
Chain Length:158
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P01375
Ligand Molecules
NA
Primary Citation
Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNF alpha NANOBODY® compound.
Biochem.Biophys.Res.Commun. 816 153572 153572 (2026)
PMID: 41935434 DOI: 10.1016/j.bbrc.2026.153572
Primary Citation of related structures
21TW
Feedback Form
Name
Email
Institute
Feedback