21TV image
Deposition Date 2025-12-26
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
21TV
Keywords:
CYTOKINE
Title:
Cryo-EM structure of the TNF-alpha-Ozoralizumab (OZR)-HSA complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Cricetulus griseus, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
6.19 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
21TV validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ozoralizumab (OZR)
Chain IDs:A
Chain Length:363
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:21TV
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor
Gene (Uniprot):TNF
Chain IDs:B, C, D
Chain Length:158
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P01375
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serum albumin
Gene (Uniprot):ALB
Chain IDs:E
Chain Length:585
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P02768
Ligand Molecules
NA
Primary Citation
Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNF alpha NANOBODY® compound.
Biochem.Biophys.Res.Commun. 816 153572 153572 (2026)
PMID: 41935434 DOI: 10.1016/j.bbrc.2026.153572
Primary Citation of related structures
21TV
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