21TI image
Deposition Date 2025-12-23
Release Date 2026-10-07
Last Version Date 2026-10-21
Entry Detail
PDB ID:
21TI
Keywords:
TRANSFERASE
Title:
Enterovirus 71 Polymerase (S417G mutant) Elongation Complex with Remdesivir Nucleotides at Product Strand Positions -3 and -5 (C2S4 form)
Biological Source:
Source Organism(s):
Enterovirus A71 (Taxon ID: 39054)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.22 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 21 21 21
21TI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enterovirus 71 polymerase
Mutagens:C291M, S417G
Chain IDs:A
Chain Length:468
Number of Molecules:1
Biological Source:Enterovirus A71
UniProt ID:E5RPG3 EC:3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48
Polymer Type:polyribonucleotide
Molecule:RNA (34-MER)
Chain IDs:B
Chain Length:34
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*GP*UP*UP*CP*GP*
Chain IDs:C
Chain Length:17
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
MN
POP
SO4
ZN
Primary Citation
Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide
Nucleic Acids Res. ? ? ? (2026)
DOI: 10.1093/nar/gkag957
Primary Citation of related structures
21TI
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