ISDA: 21RP

Deposition Date 2025-12-23

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

21RP

Keywords:

RNA BINDING PROTEIN/DNA

Title:

DRT4 homohexamer with dATP

Biological Source:

Source Organism(s):

Enterobacteriaceae (Taxon ID: 543)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.84 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Reverse transcriptase domain-
Gene (Uniprot):BZ227_14395
Chain IDs:A, B, C, D, E, F
Chain Length:540
Number of Molecules:6
Biological Source:Enterobacteriaceae

UniProt ID:A0A628R156

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*AP*AP*AP*AP*A)-3'
Chain IDs:G, H, I, J, K, L
Chain Length:5
Number of Molecules:6
Biological Source:Escherichia coli

Ligand Molecules

DTP

Primary Citation

DNA polymerization activates RNA cleavage of a reverse transcriptase-like antiviral enzyme

Rong, X, Xiao, J, Zhao, X, Yan, Y, Li, J, Chen, Y, Fan, Y, Liu, Z, Cao, Y, Chen, F, Cheng, R, Wang, X, Wang, L, Zhu, B.Show

Science ? ? ? (2026)

DOI: 10.1126/science.aef3178

Primary Citation of related structures

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