ISDA: 21KU

Deposition Date 2025-12-17

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

21KU

Keywords:

HYDROLASE

Title:

Structure of Pseudomonas aeruginosa mutant ClpP2-R140A

Biological Source:

Source Organism(s):

Pseudomonas aeruginosa PAO1 (Taxon ID: 208964)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.00 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Mutagens:R140A
Chain IDs:A (auth: R), B (auth: Z), C (auth: A), D (auth: B), E (auth: C), F (auth: D), G (auth: E), H (auth: F), I (auth: G), J (auth: H), K (auth: I), L (auth: J), M (auth: K), N (auth: L), O (auth: M), P (auth: N), Q (auth: O), R (auth: P), S (auth: Q), T (auth: S), U (auth: T), V (auth: U), W (auth: V), X (auth: W), Y (auth: X), Z (auth: Y), AA (auth: a), BA (auth: b)
Chain Length:207
Number of Molecules:28
Biological Source:Pseudomonas aeruginosa PAO1

UniProt ID:Q9HYR9 EC:3.4.21.92

Primary Citation

Structural and Pharmacological Basis for the State-Dependent Activation of the Autoinhibited P. aeruginosa ClpP2 Protease.

Zhao, N, Ma, H, Zhu, Z, Fan, D, Dai, D, Mou, X, Zhou, J, Li, Y, Gao, M, Chenghuang, J, Liu, S, Huang, H, Bao, R.Show

Acs Chem.Biol. 21 1383 1396 (2026)

PMID: 42119043 DOI: 10.1021/acschembio.6c00141

Primary Citation of related structures

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