21IE image
Deposition Date 2025-12-13
Release Date 2026-02-04
Last Version Date 2026-08-19
Entry Detail
PDB ID:
21IE
Keywords:
NUCLEAR PROTEIN
Title:
The MIDN Catch-IRF4 (A8S) fusion protein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.24 Å
R-Value Free:
0.29
R-Value Work:
0.27
R-Value Observed:
0.27
Space Group:
P 65 2 2
21IE validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Midnolin,Interferon regulator
Gene (Uniprot):MIDN, IRF4
Mutagens:A222M
Chain IDs:A
Chain Length:65
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q504T8,Q15306
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Midnolin
Gene (Uniprot):MIDN
Chain IDs:B
Chain Length:73
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q504T8
Ligand Molecules
NA
Primary Citation
Biochemical and structural studies of the midnolin Catch domain bound with both wild-type and mutant IRF4 peptides reveal the molecular basis for its broad substrate specificity.
Acta Biochim.Biophys.Sin. 58 1235 1249 (2026)
PMID: 41531205 DOI: 10.3724/abbs.2026002
Primary Citation of related structures
21IE
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