21HJ image
Deposition Date 2025-12-12
Release Date 2026-03-11
Last Version Date 2026-09-23
Entry Detail
PDB ID:
21HJ
Keywords:
PROTEIN BINDING
Title:
Solution structures of BRD9 bromodomain in complex with histone H3 lactyl-lysine 18 (H3K18la) peptide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
SOLUTION NMR
Conformers Calculated:
200
Conformers Submitted:
20
Selection Criteria:
structures with the lowest energy
21HJ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD9
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H8M2 Pfam ID:PF00439
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone H3.3C
Gene (Uniprot):H3-5
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6NXT2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
XRW B LYS modified residue
Ligand Molecules
NA
Primary Citation
BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma.
Cell Death Differ. ? ? ? (2026)
PMID: 41792243 DOI: 10.1038/s41418-026-01698-6
Primary Citation of related structures
21HJ
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