ISDA: 21ET

Deposition Date 2025-12-10

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

21ET

Keywords:

RNA

Title:

1'-sugar-tethered cholesterol-modified siRNA

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.24

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*GP*GP*AP*CP*UP*CP*
Chain IDs:A, B, C, D, E, F
Chain Length:13
Number of Molecules:6
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

1'-Sugar-Tethered Cholesterol-Modified siRNAs with Variable Linker Lengths for Carrier-Free Delivery and Enhanced RNAi Efficiency

Shimada, Y, Tsuchida, A, Ando, S, Kakisawa, Y, Kohda, Y, Ogata, A, Mahmoud, E.M, Kondo, J, Sakamoto, S, Ueno, Y.Show

Acs Omega ? ? ? (2026)

DOI: 10.1021/acsomega.6c02915

Primary Citation of related structures

Feedback Form