21ES image
Deposition Date 2025-12-10
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
21ES
Keywords:
SIGNALING PROTEIN
Title:
Structural and Functional Insights into VEGFR-3-Mediated Lymphangiogenesis : Unraveling the clustering mechanism of VEGFR-3/VEGF-C
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
3D ARRAY
Reconstruction Method:
SINGLE PARTICLE
21ES validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Vascular endothelial growth f
Gene (Uniprot):FLT4
Chain IDs:A, B, C (auth: E), D (auth: F)
Chain Length:0
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P35916 Pfam ID:PF22854, PF21339, PF13927, PF22971, PF07679 EC:2.7.10.1
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Vascular endothelial growth f
Gene (Uniprot):VEGFC
Chain IDs:E (auth: C), F (auth: D), G, H
Chain Length:0
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P49767 Pfam ID:PF00341
Ligand Molecules
NA
Primary Citation
Structural Basis of Lymphangiogenic Receptor VEGFR-3 Activation Mediated by Distinctive Clustering of the Ligand-Receptor Complex.
Adv Sci ? e77728 e77728 (2026)
PMID: 42717534 DOI: 10.1002/advs.77728
Primary Citation of related structures
21EI
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