ISDA: 21EE

Deposition Date 2025-12-10

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

21EE

Keywords:

PROTEIN BINDING

Title:

Crystal structure of human PHF20L1(1-80) in complex with H3K36me

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.34 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:PHD finger protein 20-like pr
Chain IDs:A
Chain Length:80
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Histone H3.1t
Chain IDs:B
Chain Length:15
Number of Molecules:1
Biological Source:Homo sapiens

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MLZ	B	LYS	modified residue

Primary Citation

A revised model for PHF20L1 Tudor function: DNA binding overrides methylation selectivity on nucleosomes.

Huang, X, Xiao, Q, Liu, X, Shang, X, Wang, Z, Hu, H, Zhou, Y, Huang, Q, Jiang, T, Qin, S, Huang, Y, Li, J.B, Liu, Y.Show

J.Biol.Chem. 302 113181 113181 (2026)

PMID: 42173250 DOI: 10.1016/j.jbc.2026.113181

Primary Citation of related structures

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