ISDA: 21BH

Deposition Date 2025-12-06

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

21BH

Keywords:

ANTIVIRAL PROTEIN/RNA

Title:

Cryo-EM structure of type VII CRISPR-Cas complex at the target engagement state

Biological Source:

Source Organism(s):

metagenome (Taxon ID: 256318)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:a protein
Chain IDs:A (auth: B), B (auth: C), C (auth: D), D (auth: E), E (auth: F), I (auth: J), N (auth: O)
Chain Length:200
Number of Molecules:7
Biological Source:metagenome

UniProt ID:21BH

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:a protein
Chain IDs:F (auth: G)
Chain Length:240
Number of Molecules:1
Biological Source:metagenome

UniProt ID:21BH

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:a protein
Chain IDs:G (auth: H), H (auth: I), J (auth: K), K (auth: L)
Chain Length:609
Number of Molecules:4
Biological Source:metagenome

UniProt ID:21BH

Polymer Type:polyribonucleotide
Molecule:RNA (54-MER)
Chain IDs:L (auth: M)
Chain Length:54
Number of Molecules:1
Biological Source:metagenome

Polymer Type:polyribonucleotide
Molecule:RNA (60-MER)
Chain IDs:M (auth: N)
Chain Length:60
Number of Molecules:1
Biological Source:metagenome

Ligand Molecules

Primary Citation

Allosteric activation mechanism of the type VII CRISPR-Cas system.

Zhang, S, Liu, Y, Wu, W, Liu, Z, He, Q, Wang, T, Yang, J, Yin, H, Yuan, Z, Zhang, H.Show

Nucleic Acids Res. 54 ? ? (2026)

PMID: 41954985 DOI: 10.1093/nar/gkag314

Primary Citation of related structures

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