ISDA: 20YC

Deposition Date 2025-12-02

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

20YC

Keywords:

SIGNALING PROTEIN

Title:

Cryo-EM structure of GPR174-Gi complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.40 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:338
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: C)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable G-protein coupled re
Gene (Uniprot):GPR174
Chain IDs:B (auth: R)
Chain Length:333
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BXC1 Pfam ID:PF00001

Ligand Molecules

Primary Citation

Hydration network drives activation and G protein selectivity in GPR174

Dong, Y.-J, Xi, K, Zhang, Y.-Z, Xue, J.-H, Shen, D.-D, Zang, S.-K, Zhao, R.-Z, Qi, H, Mao, C.-Y, Wang, W.-W, Zhang, Y.Show

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Primary Citation of related structures

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