ISDA: 1NXI

Deposition Date 2003-02-10

Release Date 2003-07-01

Last Version Date 2024-05-08

Entry Detail

PDB ID:

1NXI

Keywords:

STRUCTURAL GENOMICS, UNKNOWN FUNCTION

Title:

Solution structure of Vibrio cholerae protein VC0424

Biological Source:

Source Organism(s):

Vibrio cholerae (Taxon ID: 666)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

Conformers Submitted:

Selection Criteria:

all calculated structures submitted

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:conserved hypothetical protei
Gene (Uniprot):rraB
Chain IDs:A
Chain Length:132
Number of Molecules:1
Biological Source:Vibrio cholerae

UniProt ID:Q9KUU1 Pfam ID:PF06877

Ligand Molecules

Primary Citation

Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold.

Ramelot, T.A, Ni, S, Goldsmith-Fischman, S, Cort, J.R, Honig, B, Kennedy, M.A.Show

Protein Sci. 12 1556 1561 (2003)

PMID: 12824501 DOI: 10.1110/ps.03108103

Abstact

The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076). The structure has an alpha-beta sandwich architecture consisting of two layers: a four-stranded antiparallel beta-sheet and three side-by-side alpha-helices. The secondary structure elements have the order alphabetaalphabetabetaalphabeta along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the beta-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins.

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Primary Citation of related structures

Abstact

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