ISDA: 1BT5

Deposition Date 1998-09-02

Release Date 1999-09-02

Last Version Date 2024-11-20

Entry Detail

PDB ID:

1BT5

Keywords:

HYDROLASE

Title:

CRYSTAL STRUCTURE OF THE IMIPENEM INHIBITED TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.23

R-Value Work:

0.17

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PROTEIN (BETA-LACTAMASE)
Gene (Uniprot):bla, blaT-3, blaT-4, blaT-5, blaT-6
Mutagens:V82I, A182V
Chain IDs:A
Chain Length:263
Number of Molecules:1
Biological Source:Escherichia coli

UniProt ID:P62593 Pfam ID:PF00144, PF13354 EC:3.5.2.6

Ligand Molecules

IM2

SO4

Primary Citation

Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria

Maveyraud, L, Mourey, L, Kotra, L.P, Pedelacq, J.D, Guillet, V, Mobashery, S, Samama, J.P.Show

J.Am.Chem.Soc. 120 9748 9752 (1998)

Primary Citation of related structures

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