ISDA: 14CU

Deposition Date 2026-04-28

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

14CU

Keywords:

TRANSFERASE

Title:

Structure of liver pyruvate kinase in complex with allosteric site binder 8g

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.39 Å

R-Value Free:

0.28

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform L-type of Pyruvate ki
Gene (Uniprot):PKLR
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:447
Number of Molecules:8
Biological Source:Homo sapiens

UniProt ID:P30613 EC:2.7.1.40

Ligand Molecules

FBP

OXL

WWD

Primary Citation

Symmetry-Guided Fusion Converts Weak Liver Pyruvate Kinase inhibitors into potent Allosteric Activators

Monjas, L, Rodriguez-Rivero, A, Fuchtbauer, A.F.F, Nilsson, O, Haversen, L, Lulla, A, Brear, P, Rutberg, M, Bergh, P.O, Boren, J, MARDINOGLU, A, Hyvonen, M, Grotli, M.Show

Rsc Med Chem ? ? ? (2026)

DOI: 10.1039/D6MD00604C

Primary Citation of related structures

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