ISDA: 13GK

Deposition Date 2026-05-05

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

13GK

Keywords:

TRANSFERASE

Title:

CDK2 in complex with INCB125496

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.44 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclin-dependent kinase 2
Gene (Uniprot):CDK2
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P24941 Pfam ID:PF00069 EC:2.7.11.22

Ligand Molecules

A1DFY

GOL

PEG

Primary Citation

Discovery of INCB127443: A Potent and Orally Available Inhibitor of Cyclin-Dependent Kinase 2

Mukai, K, Smith, B.R, Ye, Q, Epling, L.B, Lai, C, Huo, L, Bowen, S, Drake, K, Kennedy, K, Boer, J, Zimmer, D, Zhang, W, Hansbury, M.J, Chand, S, Li, J, Zhang, G, Stump, K, Lo, Y, Favata, M, Yang, G, Covington, M, Deller, M.C, Macarron, R, Jackson, J, Mayes, P, Kim, S, Wang, X, Hummel, J.R, Yao, W.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c01506

Primary Citation of related structures

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