ISDA: 13DZ

Deposition Date 2026-05-01

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

13DZ

Keywords:

OXIDOREDUCTASE

Title:

X-ray crystal structure of human biliverdin beta IX reductase in complex with NADP and BCT002104

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.72 Å

R-Value Free:

0.22

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Flavin reductase (NADPH)
Gene (Uniprot):BLVRB
Chain IDs:A
Chain Length:210
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P30043 Pfam ID:PF13460 EC:1.3.1.24

Ligand Molecules

A1DFI

GOL

NAP

Primary Citation

A Structure-guided Active Site Affinity Ligand Unmasks a Stress-Sensitizing Role for BLVRB in the Endoplasmic Reticulum.

Thekke Veedu, R.R, Sheriff, J, Nesbitt, N.M, Marchenko, N, Pennacchia, L, Ginex, T, Hearing, P, Kreitler, D.F, Bahou, W.F.Show

J.Med.Chem. ? ? ? (2026)

PMID: 42505148 DOI: 10.1021/acs.jmedchem.6c01466

Primary Citation of related structures

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