13DE image
Deposition Date 2026-04-30
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
13DE
Keywords:
Title:
Cryo-EM structure of ATR-ATRIP-ETAA1 AAD (S95D/S111D)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):ATR
Chain IDs:A, C (auth: B)
Chain Length:2663
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:ATR-interacting protein
Gene (Uniprot):ATRIP
Chain IDs:B (auth: C), D
Chain Length:810
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Ewing's tumor-associated anti
Gene (Uniprot):ETAA1
Mutagens:S95D, S111D
Chain IDs:E (auth: F), F (auth: E)
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens
Primary Citation
Structural mechanism of TOPBP1 activating the ATR-ATRIP replication checkpoint kinase.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42493622 DOI: 10.1038/s41594-026-01844-1
Primary Citation of related structures
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