ISDA: 12YI

Deposition Date 2026-04-22

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

12YI

Keywords:

TRANSFERASE

Title:

The GNMT N-Terminal Domain Orchestrates Folate-Dependent Regulation of Cellular Methylation Dynamics

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.22

R-Value Work:

0.16

R-Value Observed:

0.20

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glycine N-methyltransferase
Gene (Uniprot):GNMT
Chain IDs:A, B, C, D
Chain Length:295
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q14749 Pfam ID:PF13649 EC:2.1.1.20

Ligand Molecules

PO4

Primary Citation

The GNMT N-Terminal Domain Orchestrates Folate-Dependent Regulation of Cellular Methylation Dynamics

Kraz, I, Lorton, B.M, Harijan, R.K, Hedge, S, Bonanno, J.B, Shechter, D.Show

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Primary Citation of related structures

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