ISDA: 12UW

Deposition Date 2026-04-20

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

12UW

Keywords:

ONCOPROTEIN

Title:

Crystal structure of KRAS(Q61K) bound to GDP and ligand

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Mutagens:Q61K
Chain IDs:A, B
Chain Length:170
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1DEM

GDP

Primary Citation

Bronsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants.

Wang, Y.C, Chen, S.C, Cao, Y, Wu, Y, Shi, Z, Wang, C.D, Norinskiy, M.A, Celik, H, Zhang, Z.Show

Nat.Chem.Biol. ? ? ? (2026)

PMID: 42587080 DOI: 10.1038/s41589-026-02291-1

Primary Citation of related structures

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