12UU image
Deposition Date 2026-04-20
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
12UU
Keywords:
VIRUS
Title:
The AAV2 capsid in complex with IgG-Fab#3-4
Biological Source:
Source Organism(s):
adeno-associated virus 2 (Taxon ID: 10804)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.91 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12UU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Capsid protein VP1
Gene (Uniprot):VP1
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, AA (auth: 1), BA (auth: 2), CA (auth: 3), DA (auth: 4), EA (auth: 5), FA (auth: 6), GA (auth: a), HA (auth: b), IA (auth: c), JA (auth: d), KA (auth: e), LA (auth: f), MA (auth: g), NA (auth: h), OA (auth: i), PA (auth: j), QA (auth: k), RA (auth: l), SA (auth: m), TA (auth: n), UA (auth: o), VA (auth: p), WA (auth: q), XA (auth: r), YA (auth: s), ZA (auth: t), AB (auth: u), BB (auth: v), CB (auth: w), DB (auth: x), EB (auth: y), FB (auth: z), GB (auth: 7), HB (auth: 8)
Chain Length:0
Number of Molecules:60
Biological Source:adeno-associated virus 2
UniProt ID:P03135 Pfam ID:PF00740 EC:3.1.1.4
Polymer Type:polypeptide(L)
Molecule:IgG Fab3-4 heavy chain
Chain IDs:IB (auth: Ah), JB (auth: Bh), KB (auth: Ch), LB (auth: Dh), MB (auth: Eh), NB (auth: Fh), OB (auth: Gh), PB (auth: Hh), QB (auth: Ih), RB (auth: Jh), SB (auth: Kh), TB (auth: Lh), UB (auth: Mh), VB (auth: Nh), WB (auth: Oh), XB (auth: Ph), YB (auth: Qh), ZB (auth: Rh), AC (auth: Sh), BC (auth: Th), CC (auth: Uh), DC (auth: Vh), EC (auth: Wh), FC (auth: Xh), GC (auth: Yh), HC (auth: Zh), IC (auth: 1h), JC (auth: 2h), KC (auth: 3h), LC (auth: 4h), MC (auth: 5h), NC (auth: 6h), OC (auth: ah), PC (auth: bh), QC (auth: ch), RC (auth: dh), SC (auth: eh), TC (auth: fh), UC (auth: gh), VC (auth: hh), WC (auth: ih), XC (auth: jh), YC (auth: kh), ZC (auth: lh), AD (auth: mh), BD (auth: nh), CD (auth: oh), DD (auth: ph), ED (auth: qh), FD (auth: rh), GD (auth: sh), HD (auth: th), ID (auth: uh), JD (auth: vh), KD (auth: wh), LD (auth: xh), MD (auth: yh), ND (auth: zh), OD (auth: 7h), PD (auth: 8h)
Chain Length:0
Number of Molecules:60
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:IgG Fab3-4 light chain
Chain IDs:QD (auth: Al), RD (auth: Bl), SD (auth: Cl), TD (auth: Dl), UD (auth: El), VD (auth: Fl), WD (auth: Gl), XD (auth: Hl), YD (auth: Il), ZD (auth: Jl), AE (auth: Kl), BE (auth: Ll), CE (auth: Ml), DE (auth: Nl), EE (auth: Ol), FE (auth: Pl), GE (auth: Ql), HE (auth: Rl), IE (auth: Sl), JE (auth: Tl), KE (auth: Ul), LE (auth: Vl), ME (auth: Wl), NE (auth: Xl), OE (auth: Yl), PE (auth: Zl), QE (auth: 1l), RE (auth: 2l), SE (auth: 3l), TE (auth: 4l), UE (auth: 5l), VE (auth: 6l), WE (auth: al), XE (auth: bl), YE (auth: cl), ZE (auth: dl), AF (auth: el), BF (auth: fl), CF (auth: gl), DF (auth: hl), EF (auth: il), FF (auth: jl), GF (auth: kl), HF (auth: ll), IF (auth: ml), JF (auth: nl), KF (auth: ol), LF (auth: pl), MF (auth: ql), NF (auth: rl), OF (auth: sl), PF (auth: tl), QF (auth: ul), RF (auth: vl), SF (auth: wl), TF (auth: xl), UF (auth: yl), VF (auth: zl), WF (auth: 7l), XF (auth: 8l)
Chain Length:0
Number of Molecules:60
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Broadly cross-reactive anti-capsid IgA is an overlooked antibody 1 barrier in AAV2 mediated gene transfer
Nat Commun ? ? ? (2026)
Primary Citation of related structures
12UU
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