12UT image
Deposition Date 2026-04-20
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
12UT
Keywords:
VIRUS
Title:
The AAV2 capsid in complex with IgA-Fab#3-2
Biological Source:
Source Organism(s):
adeno-associated virus 2 (Taxon ID: 10804)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Cricetulus griseus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.48 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12UT validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Capsid protein VP1
Gene (Uniprot):VP1
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, AA (auth: a), BA (auth: b), CA (auth: c), DA (auth: d), EA (auth: e), FA (auth: f), GA (auth: g), HA (auth: h), IA (auth: i), JA (auth: j), KA (auth: k), LA (auth: l), MA (auth: m), NA (auth: n), OA (auth: o), PA (auth: p), QA (auth: q), RA (auth: r), SA (auth: s), TA (auth: t), UA (auth: u), VA (auth: v), WA (auth: w), XA (auth: x), YA (auth: y), ZA (auth: z), AB (auth: 0), BB (auth: 1), CB (auth: 2), DB (auth: 3), EB (auth: 4), FB (auth: 5), GB (auth: 6), HB (auth: 7)
Chain Length:0
Number of Molecules:60
Biological Source:adeno-associated virus 2
UniProt ID:P03135 Pfam ID:PF00740 EC:3.1.1.4
Polymer Type:polypeptide(L)
Molecule:IgA-Fab3-2 Heavy chain
Chain IDs:IB (auth: Ah), JB (auth: Bh), KB (auth: Ch), LB (auth: Dh), MB (auth: Eh), NB (auth: Fh), OB (auth: Gh), PB (auth: Hh), QB (auth: Ih), RB (auth: Jh), SB (auth: Kh), TB (auth: Lh), UB (auth: Mh), VB (auth: Nh), WB (auth: Oh), XB (auth: Ph), YB (auth: Qh), ZB (auth: Rh), AC (auth: Sh), BC (auth: Th), CC (auth: Uh), DC (auth: Vh), EC (auth: Wh), FC (auth: Xh), GC (auth: Yh), HC (auth: Zh), IC (auth: ah), JC (auth: bh), KC (auth: ch), LC (auth: dh), MC (auth: eh), NC (auth: fh), OC (auth: gh), PC (auth: hh), QC (auth: ih), RC (auth: jh), SC (auth: kh), TC (auth: lh), UC (auth: mh), VC (auth: nh), WC (auth: oh), XC (auth: ph), YC (auth: qh), ZC (auth: rh), AD (auth: sh), BD (auth: th), CD (auth: uh), DD (auth: vh), ED (auth: wh), FD (auth: xh), GD (auth: yh), HD (auth: zh), ID (auth: 0h), JD (auth: 1h), KD (auth: 2h), LD (auth: 3h), MD (auth: 4h), ND (auth: 5h), OD (auth: 6h), PD (auth: 7h)
Chain Length:0
Number of Molecules:60
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:IgA-Fab3-2 Light chain
Chain IDs:QD (auth: Al), RD (auth: Bl), SD (auth: Cl), TD (auth: Dl), UD (auth: El), VD (auth: Fl), WD (auth: Gl), XD (auth: Hl), YD (auth: Il), ZD (auth: Jl), AE (auth: Kl), BE (auth: Ll), CE (auth: Ml), DE (auth: Nl), EE (auth: Ol), FE (auth: Pl), GE (auth: Ql), HE (auth: Rl), IE (auth: Sl), JE (auth: Tl), KE (auth: Ul), LE (auth: Vl), ME (auth: Wl), NE (auth: Xl), OE (auth: Yl), PE (auth: Zl), QE (auth: al), RE (auth: bl), SE (auth: cl), TE (auth: dl), UE (auth: el), VE (auth: fl), WE (auth: gl), XE (auth: hl), YE (auth: il), ZE (auth: jl), AF (auth: kl), BF (auth: ll), CF (auth: ml), DF (auth: nl), EF (auth: ol), FF (auth: pl), GF (auth: ql), HF (auth: rl), IF (auth: sl), JF (auth: tl), KF (auth: ul), LF (auth: vl), MF (auth: wl), NF (auth: xl), OF (auth: yl), PF (auth: zl), QF (auth: 0l), RF (auth: 1l), SF (auth: 2l), TF (auth: 3l), UF (auth: 4l), VF (auth: 5l), WF (auth: 6l), XF (auth: 7l)
Chain Length:0
Number of Molecules:60
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Broadly cross-reactive anti-capsid IgA is an overlooked antibody 1 barrier in AAV2 mediated gene transfer
Nat Commun ? ? ? (2026)
Primary Citation of related structures
12UT
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