12PB image
Deposition Date 2026-04-14
Release Date 2026-05-13
Last Version Date 2026-07-08
Entry Detail
PDB ID:
12PB
Keywords:
MEMBRANE PROTEIN
Title:
Single particle cryo-EM structure of human MTCH2 (hyperactive mutant K25E Y235A V238D)
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3), Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12PB validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial carrier homolog
Gene (Uniprot):UCP1, MTCH2
Mutagens:K25E,Y235A,V238D,L199V,A200Y,T226A
Chain IDs:B (auth: A)
Chain Length:304
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y6C9,P25874 Pfam ID:PF00153
Polymer Type:polypeptide(L)
Molecule:UCP1 Nanobody
Chain IDs:A (auth: B)
Chain Length:127
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
Structural evolution of the MTCH family of mitochondrial insertases.
Sci Adv 12 eaeh2957 eaeh2957 (2026)
PMID: 42308315 DOI: 10.1126/sciadv.aeh2957
Primary Citation of related structures
12PB
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