ISDA: 12OY

Deposition Date 2026-04-14

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

12OY

Keywords:

MEMBRANE PROTEIN

Title:

Single particle cryo-EM structure of human MTCH2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial carrier homolog
Gene (Uniprot):UCP1, MTCH2
Mutagens:L199V, A200Y, T226A
Chain IDs:A
Chain Length:304
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y6C9,P25874

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:UCP1 Nanobody
Chain IDs:B
Chain Length:127
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:12OY

Ligand Molecules

Primary Citation

Structural evolution of the MTCH family of mitochondrial insertases

Luo, Z, Stevens, T.A, Lee, C.A, Hazu, M, Galatis, E.G, Inglis, A.J, Guna, A, Voorhees, R.M.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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