ISDA: 12IZ

Deposition Date 2026-04-07

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

12IZ

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human cannabinoid receptor 2-Gi complex with agonist '5249

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.72 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503 EC:3.6.5.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cannabinoid receptor 2
Gene (Uniprot):CNR2
Chain IDs:E (auth: R)
Chain Length:374
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P34972 Pfam ID:PF00001

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ScFv16
Chain IDs:D (auth: S)
Chain Length:281
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

A1DB5

Primary Citation

Library Docking for Cannabinoid-2 Receptor Ligands.

Rachman, M.M, Iliopoulos-Tsoutsouvas, C, Sacco, M.D, Xu, X, Wu, C.G, Santos, E, Glenn, I.S, Paris, L, Cahill, M.K, Ganapathy, S, Tummino, T.A, Moroz, Y.S, Radchenko, D.S, Okorie, M, Tawfik, V.L, Irwin, J.J, Makriyannis, A, Skiniotis, G, Shoichet, B.K.Show

J.Med.Chem. ? ? ? (2026)

PMID: 42397716 DOI: 10.1021/acs.jmedchem.6c00835

Primary Citation of related structures

Feedback Form