ISDA: 12GB

Deposition Date 2026-04-03

Release Date 2026-04-15

Last Version Date 2026-07-22

Entry Detail

PDB ID:

12GB

Keywords:

PROTEIN FIBRIL

Title:

High Resolution Structure of Monomorphic AB1-40 Fibrils

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

SOLID-STATE NMR

Conformers Calculated:

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Type IIIb beta-amyloid 40 Fil
Gene (Uniprot):APP
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Chain Length:40
Number of Molecules:20
Biological Source:Homo sapiens

UniProt ID:P05067 Pfam ID:PF03494

Ligand Molecules

Primary Citation

High-resolution structure of monomorphic A beta 1-40 fibrils.

Bahri, S, Palani, R.S, Silvers, R, Michael, B, Lattanzi, V, Andre, I, Linse, S, Griffin, R.G.Show

Proc.Natl.Acad.Sci.USA 123 e2603575123 e2603575123 (2026)

PMID: 42418485 DOI: 10.1073/pnas.2603575123

Primary Citation of related structures

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