ISDA: 12ES

Deposition Date 2026-03-31

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

12ES

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of BCMA in complex with the BCMA-targeted Fab arm of linvoseltamab and the Fab fragment of an anti-kappa light chain antibody REGN654

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Cricetulus griseus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.43 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Heavy chain of the Fab fragme
Chain IDs:A
Chain Length:223
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Light chain of the Fab fragme
Chain IDs:B
Chain Length:214
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor recepto
Chain IDs:C
Chain Length:82
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Heavy chain of the BCMA-targe
Chain IDs:D
Chain Length:227
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Light chain of the BCMA-targe
Chain IDs:E
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

DISTINCT EPITOPE ENGAGEMENT CONFERS DIFFERENTIAL ACTIVITY OF LINVOSELTAMAB VERSUS TECLISTAMAB ACROSS BCMA MUTATIONS.

Zhou, Y, Sineshchekova, O, Lee, K, Doshi, A, Brown, K, Franklin, M.C, Ullman, E, Hermann, A, Kroog, G.S, Boyapati, A, Smith, E, Lin, J.C, Olson, W.C, Olson, K.Show

Blood Adv ? ? ? (2026)

PMID: 42509021 DOI: 10.1182/bloodadvances.2026020381

Primary Citation of related structures

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