ISDA: 12BP

Deposition Date 2026-03-25

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

12BP

Keywords:

HYDROLASE

Title:

Cryo-EM structure of human DDB1-CRBN-GSPT1 in complex with GT19630

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Eukaryotic peptide chain rele
Chain IDs:A (auth: X)
Chain Length:218
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Chain IDs:C (auth: Y)
Chain Length:836
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Chain IDs:B (auth: Z)
Chain Length:406
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules