12BN image
Deposition Date 2026-03-25
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
12BN
Keywords:
BLOOD CLOTTING
Title:
Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryoEM
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12BN validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coagulation factor XIa heavy
Gene (Uniprot):F11
Chain IDs:C (auth: A), E (auth: C)
Chain Length:369
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P03951 Pfam ID:PF00024, PF00089 EC:3.4.21.27
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coagulation factor XIa light
Gene (Uniprot):F11
Mutagens:S557A
Chain IDs:D (auth: B), F (auth: D)
Chain Length:236
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P03951 Pfam ID:PF00024, PF00089 EC:3.4.21.27
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coagulation factor IX
Gene (Uniprot):F9
Chain IDs:A (auth: E), B (auth: F)
Chain Length:415
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P00740 Pfam ID:PF00594, PF00008, PF14670, PF00089 EC:3.4.21.22
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CGU A GLU modified residue
Ligand Molecules
CA
NAG
Primary Citation
Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryo-EM.
J.Thromb.Haemost. ? ? ? (2026)
PMID: 42628751 DOI: 10.1016/j.jtha.2026.08.015
Primary Citation of related structures
12BN
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